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KMID : 0352120170320010016
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Journal of Kyung Hee University
2017 Volume.32 No. 1 p.16 ~ p.25
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Oral Prednisolone Therapy for Refractory Mycoplasma pneumoniae Pneumonia in Children
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Song Ho-Young
Kang Soo-Yeon
Song Joon-Hyuk
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Abstract
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Purpose: Mycoplasma pneumoniae (M. pneumoniae) is one of the most common causes of communityacquired pneumonia in children. The progression of M. pneumoniae infection is self-limited and benign. Rarely, progression to severe pneumonia occurs despite appropriate antibiotic therapy. The aim of this study was to investigate the effects of oral prednisolone therapy for refractory M. pneumoniae pneumonia (MP) in children.
Methods: M. pneumoniae infection was diagnosed serologically. Refractory MP was defined as follows: clinical symptoms and radiologic findings worsened despite appropriate antibiotic therapy including macrolides. We retrospectively evaluated in 12 children with refractory MP.
Results: We administered oral prednisolone (1 mg/kg/day) in addition to antibiotics. All patients responded well to oral prednisolone therapy. Fever persisted in all 12 children until steroid administration. However, all patients who received prednisolone therapy showed rapid defervescence within 24 hours and clinical symptoms improved without adverse events. The high C-reactive protein levels (8.1±7.0 mg/dL) decreased to 4.7±4.4 mg/dL and the abnormal radiologic findings improved within several days after initiating prednisolone therapy.
Conclusions: This study showed good outcomes of prednisolone therapy in children with refractory MP. This could be an efficacious and well-tolerated treat ment for refractory MP. Further studies may be needed to make the guideline of steroid treatment.
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KEYWORD
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Children, Prednisolone, Macrolides, Mycoplasma pneumoniae, Pneumonia
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